Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase.

Yue GuoDonghao GuoShaoting ZhangYuan ZhangXiaoyan HeXiaohua JiangAndrew Man-Lok ChanLin ZouJianmin SunHui Zhao

Published in: Cell & bioscience (2022)

In this study, we investigated the oncogenic roles of PI3K isoforms in neuroblastoma. Our data shed light on PI3K isoform p110α in the tumorigenesis of neuroblastoma, and strongly suggest the p110α inhibitors as potential drugs in treating neuroblastoma.

Keyphrases

diffuse large b cell lymphoma
signaling pathway
electronic health record
atomic force microscopy
mass spectrometry
climate change