Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies.

Harry RidgwayGraham J MooreLaura Kate GadanecAnthony ZulliVasso ApostolopoulosWeronika HoffmannKatarzyna WęgrzynNiki VassilakiGeorge MpekoulisMarios ZouridakisPetros GiastasVeroniki P VidaliKonstantinos KelaidonisMinos-Timotheos MatsoukasMarios DimitriouThomas MavromoustakosSotirios TsiodrasVasilis G GorgoulisIoannis KarakasiliotisChristos T ChasapisJohn M Matsoukas

Published in: Expert opinion on therapeutic targets (2024)

This study describes the discovery of a new class of benzimidazole-based sartans that drastically inhibit SARS-CoV-2, which could be attributed, at least in part, to their interaction with ACE2.

Keyphrases

sars cov
angiotensin converting enzyme
angiotensin ii
respiratory syndrome coronavirus
molecular docking
small molecule
hydrogen peroxide
nitric oxide
single cell