Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.
Adelle DagherAdam CuratoloMonisha SachdevAlisa J StephensChris MullinsJ Richard LandisAdrie van BokhovenAndrew El-HayekJohn W FroehlichAndrew C BriscoeRoopali RoyJiang YangMichel A PontariDavid ZurakowskiRichard S LeeMarsha A Mosesnull nullPublished in: BJU international (2017)
Altered levels of MMP-9, MMP-9/NGAL complex and VEGF-R1 in men, and all biomarkers in women, were associated with clinical symptoms of UCPPS. None of the evaluated candidate markers usefully discriminated UCPPS patients from controls. Elevated VEGF, MMP-9 and VEGF-R1 levels in men and VEGF levels in women may provide potential new insights into the pathophysiology of UCPPS.
Keyphrases
- vascular endothelial growth factor
- endothelial cells
- polycystic ovary syndrome
- end stage renal disease
- newly diagnosed
- ejection fraction
- rectal cancer
- chronic pain
- cell migration
- chronic kidney disease
- pregnancy outcomes
- peritoneal dialysis
- prognostic factors
- middle aged
- metabolic syndrome
- neuropathic pain
- cervical cancer screening
- patient reported outcomes
- skeletal muscle
- quality improvement