Combined and differential effects of alpha-thalassemia and HbF-quantitative trait loci in Senegalese hydroxyurea-free children with sickle cell anemia.

Fatou Gueye TallCyril MartinEl Hadji Malick NdourCéline RenouxIndou Déme LyPhilippe ConnesPapa Madieye GueyeRokhaya Ndiaye DialloIbrahima DiagnePape Amadou DiopAynina CisséPhilomène Lopez SallPhilippe Joly

Published in: Pediatric blood & cancer (2019)

Alpha-thalassemia -3.7 kb deletion and HbF-QTL are modulating factors of SCA clinical severity that interact with each other. They should be studied and interpreted together and not separately, at least in HU-free children.

Keyphrases

sickle cell disease
young adults
genome wide
chronic kidney disease
signaling pathway
mass spectrometry