Genetic Risk Scores Identify Genetic Aetiology of Inflammatory Bowel Disease Phenotypes.
M D VoskuilL M SpekhorstK W J van der SlootB H JansenG DijkstraC J van der WoudeF HoentjenMarieke J PierikA E van der MeulenN K H de BoerM LöwenbergB OldenburgE A M FestenR K WeersmaPublished in: Journal of Crohn's & colitis (2021)
Patients with a higher genetic burden of CD are more likely to develop fibrostenotic disease and undergo ileocaecal resection, whereas colonic CD shares genetic aetiology with PSC and UC that is largely driven by variation in MHC. These results further our understanding of specific IBD phenotypes.