Development of Tigecycline Resistance in Carbapenemase-Producing Klebsiella pneumoniae Sequence Type 147 via AcrAB Overproduction Mediated by Replacement of the ramA Promoter.

Published in: Annals of laboratory medicine (2020)

The K. pneumoniae isolate developed tigecycline resistance during tigecycline treatment. It was related to the overexpression of the AcrAB resistance-nodulation-cell division efflux system due to promoter replacement.

Keyphrases

klebsiella pneumoniae
multidrug resistant
escherichia coli
acinetobacter baumannii
transcription factor
gene expression
drug resistant
cell proliferation
single cell
gram negative
pseudomonas aeruginosa
combination therapy