Brain biomarkers and neuropsychological outcomes of pediatric posterior fossa brain tumor survivors treated with surgical resection with or without adjuvant chemotherapy.
Mary C Baron NelsonSharon H O'NeilJeffrey TanedoSofia DhananiJemily MalvarChristopher NuñezMarvin D NelsonBenita TamraziJonathan L FinlayVidya RajagopalanNatasha LeporePublished in: Pediatric blood & cancer (2020)
Posterior fossa brain tumor treatment with surgery and chemotherapy affects brain microstructure and neuropsychological functioning years into survivorship, with spatial processes the most vulnerable. Biomarkers indicating cellular changes in the thalamus, hippocampus, pons, prefrontal cortex, and white matter tracts associate with lower psychometric scores.
Keyphrases
- white matter
- prefrontal cortex
- multiple sclerosis
- mild cognitive impairment
- minimally invasive
- young adults
- coronary artery bypass
- cerebral ischemia
- resting state
- childhood cancer
- type diabetes
- coronary artery disease
- locally advanced
- adipose tissue
- metabolic syndrome
- insulin resistance
- skeletal muscle
- surgical site infection
- brain injury
- rectal cancer
- subarachnoid hemorrhage
- atrial fibrillation