UMC-PET: a fast and flexible Monte Carlo PET simulator.

Objective. The GPU-based Ultra-fast Monte Carlo positron emission tomography simulator (UMC-PET) incorporates the physics of the emission, transport and detection of radiation in PET scanners. It includes positron range, non-colinearity, scatter and attenuation, as well as detector response. The objective of this work is to present and validate UMC-PET as a a multi-purpose, accurate, fast and flexible PET simulator. Approach. We compared UMC-PET against PeneloPET, a well-validated MC PET simulator, both in preclinical and clinical scenarios. Different phantoms for scatter fraction (SF) assessment following NEMA protocols were simulated in a 6R-SuperArgus and a Biograph mMR scanner, comparing energy histograms, NEMA SF, and sensitivity for different energy windows. A comparison with real data reported in the literature on the Biograph scanner is also shown. Main results. NEMA SF and sensitivity estimated by UMC-PET where within few percent of PeneloPET predictions. The discrepancies can be attributed to small differences in the physics modeling. Running in a 11 GB GeForce RTX 2080 Ti GPU, UMC-PET is ∼1500 to ∼2000 times faster than PeneloPET executing in a single core Intel(R) Xeon(R) CPU W-2155 @ 3.30 GHz. Significance. UMC-PET employs a voxelized scheme for the scanner, patient adjacent objects (such as shieldings or the patient bed), and the activity distribution. This makes UMC-PET extremely flexible. Its high simulation speed allows applications such as MC scatter correction, faster SRM estimation for complex scanners, or even MC iterative image reconstruction.