Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota.

Akinori WadaMasaaki HigashiyamaChie KuriharaSuguru ItoRina TanemotoAkinori MizoguchiShin NishiiKenichi InabaNao SugiharaYoshinori HanawaKazuki HoriuchiNaoki ShibuyaMisaki AkiyamaYoshikiyo OkadaChikako WatanabeShunsuke KomotoKengo TomitaFumie TakeiRyota Hokari

Published in: Digestive diseases and sciences (2021)

The protective role of luminal UA in intestinal injury is likely exerted via oxidative stress elimination and microbiota composition modulation, preferably for gut immunity. Therefore, enhancing anaerobic conditions using antioxidants is a potential therapeutic target.

Keyphrases

uric acid
oxidative stress
diabetic rats
metabolic syndrome
microbial community
high glucose
wastewater treatment
dna damage
ischemia reperfusion injury
induced apoptosis
anti inflammatory
drug induced
sewage sludge
heat shock
heat shock protein
heavy metals