Circulating integrin α4 β7 + CD4 T cells are enriched for proliferative transcriptional programs in HIV infection.
Yashavanth S LakshmanappaJamin W RohNiharika N RaneAshok R DinasarapuDaphne D TranVijayakumar VeluAnandi N ShethIgho OfotokunRama R AmaraColleen F KelleyElaine WaetjenSmita S IyerPublished in: FEBS letters (2021)
HIV preferentially infects α4 β7 + CD4 T cells, forming latent reservoirs that contribute to HIV persistence during antiretroviral therapy. However, the properties of α4 β7 + CD4 T cells in blood and mucosal compartments remain understudied. Employing two distinct models of HIV infection, HIV-infected humans and simian-human immunodeficiency virus (SHIV)-infected rhesus macaques, we show that α4 β7 + CD4 T cells in blood are enriched for genes regulating cell cycle progression and cellular metabolism. Unlike their circulating counterparts, rectal α4 β7 + CD4 T cells exhibited a core tissue-residency gene expression program. These features were conserved across primate species, indicating that the environment influences memory T-cell transcriptional networks. Our findings provide an important molecular foundation for understanding the role of α4 β7 in HIV infection.
Keyphrases
- antiretroviral therapy
- human immunodeficiency virus
- hiv infected
- cell cycle
- gene expression
- hiv positive
- hiv infected patients
- hiv aids
- transcription factor
- cell proliferation
- dna methylation
- genome wide
- public health
- rectal cancer
- hiv testing
- heat shock
- working memory
- quality improvement
- ulcerative colitis
- single molecule
- hepatitis c virus
- oxidative stress