Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections.
Mohammed ElbediwiHang PanSilpak BiswasYan LiMin YuePublished in: Emerging microbes & infections (2020)
Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A retrospective study of 287 S. Newport clinical isolates collected during 1997-2018 was undertaken for characterization of AR profiles using the micro-dilution assay. We found a recent emergence of colistin resistance in four Chinese clinical isolates, including mcr-1-positive isolates. Importantly, phylogenomic and microbiological investigations indicate multiple independent clonal transmission of colistin-resistant S. Newport isolates of different seafood origins. Our study highlights potential reservoirs for transmission of colistin resistance and suggests that the global food supply chain may facilitate this dissemination.
Keyphrases
- escherichia coli
- klebsiella pneumoniae
- acinetobacter baumannii
- multidrug resistant
- pseudomonas aeruginosa
- public health
- antimicrobial resistance
- gram negative
- drug resistant
- risk factors
- high throughput
- human health
- genetic diversity
- induced pluripotent stem cells
- climate change
- risk assessment
- liquid chromatography tandem mass spectrometry