Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study.

Zhen LiBénédicte LeynaertOrianne DumasOscar Diaz GilJudith Garcia-AymerichMontserrat Fito ColomerNicole Le MoualChristophe PisonIsabelle RomieuValérie SirouxCarlos A CamargoRaphaëlle VarrasoRachel Nadif

Published in: Obesity (Silver Spring, Md.) (2019)

Leptin partly (> 60%) mediated the association between high body adiposity and persistent asthma over time. Using a newly developed analytic approach, this longitudinal study brought new insight into one mechanism by which obesity may affect asthma activity.

Keyphrases

chronic obstructive pulmonary disease
insulin resistance
lung function
allergic rhinitis
weight gain
metabolic syndrome
type diabetes
weight loss
high fat diet induced
adipose tissue
skeletal muscle
body mass index