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Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting.

Charles M ManyeloRegan S SolomonsCandice I SnydersPortia M ManngoHygon MutavhatsindiBelinda KrielKim StanleyKatharina RonacherNovel Njweipi Chegou
Published in: Mediators of inflammation (2019)
We validated a previously identified CSF biosignature and showed that refinement of this biosignature by incorporation of other biomarkers diagnosed TBM with high accuracy. Incorporation of these biomarkers into a point-of-care or bedside diagnostic test platform may result in the improved management of TBM in children.
Keyphrases
  • cerebrospinal fluid
  • young adults
  • high throughput
  • risk factors
  • amino acid