Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting.

Charles M Manyelo Regan S SolomonsCandice I SnydersPortia M ManngoHygon MutavhatsindiBelinda KrielKim StanleyKatharina Ronacher Novel Njweipi Chegou

Published in: Mediators of inflammation (2019)

We validated a previously identified CSF biosignature and showed that refinement of this biosignature by incorporation of other biomarkers diagnosed TBM with high accuracy. Incorporation of these biomarkers into a point-of-care or bedside diagnostic test platform may result in the improved management of TBM in children.

Keyphrases

cerebrospinal fluid
young adults
high throughput
risk factors
amino acid