Identification of an APOE ε4-specific blood-based molecular pathway for Alzheimer's disease risk.
Qiushan TaoChao ZhangGustavo MercierKathryn LunettaTing Fang Alvin AngSamia Akhter-KhanZhengrong ZhangAndrew TaylorRonald J KillianyMichael AloscoJesse MezRhoda AuXiaoling ZhangLindsay A FarrerWendy Wei Qiao Qiunull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2023)
Identification of an APOE ε4 specific molecular pathway involving blood CRP, C3, and CFH for the risk of AD.CRP, C3, and CFH had dose-dependent associations with CSF p-Tau and brain glucose hypometabolism as well as with cognitive impairment only in APOE ε4 homozygotes.Targeting CRP, C3, and CFH may be protective and therapeutic for AD onset in APOE ε4 carriers.