Hypocalcemia in combination with hyperphosphatemia impairs muscle cell differentiation in vitro.
V M BimonteG CatanzaroZ SpinelloM C MassariM CurreliG TerranaG DefeudisJ Halupczok-ŻyłaG MantovaniE FerrettiSilvia MigliaccioPublished in: Journal of endocrinological investigation (2023)
Our results showed that a condition of hypocalcemia with hyperphosphatemia induced an alteration of muscle cell differentiation in vitro. In particular, we observed the reduction of myogenic differentiation markers, IGF-1 signaling pathway, and ERK phosphorylation in differentiated skeletal myoblasts. These data suggest that this altered extracellular condition might contribute to the mechanisms causing persistence of symptoms in patients affected by hypoparathyroidism.
Keyphrases
- signaling pathway
- pi k akt
- skeletal muscle
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- cell proliferation
- prognostic factors
- electronic health record
- high glucose
- big data
- induced apoptosis
- patient reported outcomes
- physical activity
- depressive symptoms
- sleep quality
- endothelial cells