Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.

Sofia Bergström Julia Remnestål Jamil Yousef Jennie Olofsson Ioanna MarkakiStephanie CarvalhoJean-Christophe Corvol Kim KultimaLena KilanderMalin LöwenmarkMartin Ingelsson Kaj Blennow Henrik Zetterberg Bengt Nellgård Frederic Brosseron Michael T Heneka Beatriz Bosch Raquel Sanchez-Valle Anna Månberg Per Svenningsson Peter Nilsson

Published in: Annals of clinical and translational neurology (2021)

In conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.

Keyphrases

multidrug resistant
human health
mild cognitive impairment
cognitive decline
single cell
risk assessment
resting state
climate change
brain injury