Excess vitamin a might contribute to submucous clefting by inhibiting WNT-mediated bone formation.

Charlotte Lucienne Jacqueline Maria KrutzenLaury A RoaMarjon BloemenJohannes W Von den Hoff

Published in: Orthodontics & craniofacial research (2022)

Our data indicate that ATRA (vitamin A) inhibits bone formation by reducing Wnt signalling. This might contribute to the molecular aetiology of submucous clefting.

Keyphrases

cell proliferation
stem cells
electronic health record
signaling pathway
big data
machine learning