Morpholino-driven blockade of Dkk-1 in osteosarcoma inhibits bone damage and tumour expansion by multiple mechanisms.

Simin PanMichael CesarekCarla GodoyCynthia M CoCatherine SchindlerKelbi PadillaAndrew HaskellHeather BarredaChristopher StoryRoy PooleAlan DabneyCarl A Gregory

Published in: British journal of cancer (2022)

These results indicate that administration of DkkMo with or without chemotherapeutics can substantially improve OS outcome with respect to tumour expansion and osteolytic corruption of bone in experimental OS model.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
oxidative stress
postmenopausal women
body composition