Establishment of mouse line showing inducible priapism-like phenotypes.

Daiki HashimotoKota FujimotoShin MoriokaShinya AyabeTomoya KataokaRyutaro FukumuraYuko UedaMizuki KajimotoTaiju HyugaKentaro SuzukiIsao HaraShinichi AsamuraShigeharu WakanaAtsushi YoshikiYoichi GondoMasaru TamuraTakehiko SasakiGen Yamada

Published in: Reproductive medicine and biology (2022)

Our findings suggest that the current mutant is a mouse model for priapism and abnormalities in PI signaling pathways through PITPα may lead to priapism providing an attractive novel therapeutic target in its treatment.

Keyphrases

mouse model
signaling pathway
epithelial mesenchymal transition
pi k akt
wild type
smoking cessation