8p11.23 Amplification in Breast Cancer: Molecular Characteristics, Prognosis and Targeted Therapy.

Besides the previously proposed genes to play a role as dominant oncogenes in the 8p11.23 cancer amplified locus, other genes may also be important in breast cancer based on the high correlation of their amplification and mRNA expression and adverse prognosis conferred by over-expression, consistent with an oncogenic role.