CSF parvalbumin levels reflect interneuron loss linked with cortical pathology in multiple sclerosis.

Roberta Magliozzi Marco PitteriStefano ZiccardiAnna Isabella PisaniLuigi MontibellerDamiano MarastoniStefania RossiValentina MazziottiMaddalena GuandaliniCaterina DaporGianmarco SchiaviAgnese TamantiRichard St John NicholasRichard ReynoldsMassimiliano Calabrese

Published in: Annals of clinical and translational neurology (2021)

CSF-PVALB levels reflect loss of cortical interneurons in MS patients with more severe disease course and might represent an early, new MS-specific biomarker of cortical neurodegeneration, atrophy, and cognitive decline.

Keyphrases

multiple sclerosis
cognitive decline
mild cognitive impairment
mass spectrometry
ms ms
white matter
early onset
cerebrospinal fluid
drug induced