Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury.
Han WangXiao-Ming ZhouLing-Yun WuGuang-Jie LiuWei-Dong XuXiang-Sheng ZhangYong-Yue GaoTao TaoYan ZhouYue LuJuan WangChu-Lei DengZong ZhuangChun-Hua HangWei LiPublished in: Journal of neuroinflammation (2020)
Taken together, our data suggest that Au provides a neuroprotective effect in TBI mice model by inhibiting oxidative stress and inflammatory responses; the mechanisms involve triggering Nrf2-induced antioxidant system.
Keyphrases
- oxidative stress
- traumatic brain injury
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- severe traumatic brain injury
- high glucose
- signaling pathway
- electronic health record
- sensitive detection
- high fat diet induced
- drug induced
- mouse model
- big data
- type diabetes
- blood brain barrier
- gold nanoparticles
- reduced graphene oxide
- deep learning
- artificial intelligence