The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells.

Nicholas G NickolsEkambaram GanapathyChristine NguyenNathanael KaneLin LinSilvia Diaz-PerezRamin NazarianColleen MathisCare FelixVince BasehartNazy ZomorodianJae KwakAmar U KishanChristopher R KingPatrick A KupelianMatthew B RettigMichael L SteinbergMinsong CaoBeatrice S KnudsenFang-I ChuTahmineh RomeroDavid ElashoffRobert E ReiterDörthe Schaue

Published in: Prostate cancer and prostatic diseases (2020)

SBRT drives a significant lymphoid to myeloid shift in the prostate-tumor immune infiltrate. This may be of interest when combining SBRT with immunotherapies, particularly in prostate cancer.

Keyphrases

prostate cancer
radiation therapy
dendritic cells
induced apoptosis
bone marrow
radical prostatectomy
acute myeloid leukemia
cell cycle arrest
early stage
locally advanced
radiation induced
cell death
immune response
signaling pathway
benign prostatic hyperplasia
cell proliferation
rectal cancer