Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
Eduardo Gomez-BañuelosAmarshi MukherjeeErika DarrahFelipe AndradePublished in: Journal of clinical medicine (2019)
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated periodontal pathogens as potential triggers of the disease. In particular, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have gained interest as microbial candidates involved in RA pathogenesis by inducing the production of citrullinated antigens. Here, we will discuss the clinical and mechanistic evidence surrounding the role of these periodontal bacteria in RA pathogenesis, which highlights a key area for the treatment and preventive interventions in RA.
Keyphrases
- rheumatoid arthritis
- disease activity
- ankylosing spondylitis
- interstitial lung disease
- systemic lupus erythematosus
- oxidative stress
- physical activity
- dendritic cells
- multiple sclerosis
- systemic sclerosis
- diabetic rats
- high glucose
- climate change
- endothelial cells
- immune response
- combination therapy
- gram negative
- antimicrobial resistance