Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration.
Ayako SuzukiHans TillmannJames WilliamsRonald G HauserJulie FrundMizuki SuzukiFred W PriorGuruprasad Padur AithalMaría Isabel LucenaRaúl Jesús AndradeWeida TongChristine M HuntPublished in: Drug safety (2022)
This framework identifies unexplained acute liver injury following drug exposure in large electronic health record datasets. After validating in other systems, this framework can aid in deducing drug-induced liver injury in the general patient population and regulatory decision making to promote drug safety and public health.
Keyphrases
- drug induced
- liver injury
- public health
- electronic health record
- adverse drug
- end stage renal disease
- decision making
- ejection fraction
- newly diagnosed
- healthcare
- chronic kidney disease
- mental health
- prognostic factors
- genome wide
- peritoneal dialysis
- case report
- type diabetes
- gene expression
- respiratory failure
- dna methylation
- climate change
- human health
- insulin resistance
- acute respiratory distress syndrome
- mechanical ventilation