Transition-metal-free cascade benzannulations for synthesizing 2-hydroxybenzophenones.
Xue-Wen HeWei ZhouMin ZhangMin-Yi TianHui-Juan WangYou-Ping TianXiong-Li LiuPublished in: Organic & biomolecular chemistry (2020)
A set of cascade benzannulations of readily accessible chromone-3-carboxaldehydes and γ-nitroaldehydes for synthesizing biologically relevant 2-hydroxybenzophenones has been developed. The cascade was found to provide a transition-metal-free strategy for synthesizing 2-hydroxybenzophenones in acceptable yields (up to 57%).
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