Specificities of acute cholangitis in patients with cancer: a retrospective comparative study of 130 episodes.
Aurélien SokalSylvain ChawkiYann NguyenAlain SauvanetPhilippe PonsotFrédérique MaireBruno FantinVictoire de LastoursPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2021)
Pancreatic and biliary duct cancers are increasing causes of acute cholangitis (AC). We retrospectively characterize 81 cancer-associated cholangitis (CAC) compared to 49 non-cancer-associated cholangitis (NCAC). Clinical and biological presentations were similar. However, in CAC, antibiotic resistance and inadequate empirical antibiotic therapy were more frequent; more patients required ≥ 2 biliary drainages; and mortality at day 28 was higher than in NCAC. Death was associated with initial severity and CAC in a multivariate analysis. Cholangitis associated with pancreatic or biliary duct cancers requires specific empirical antimicrobial therapy; early use of biliary drainage may improve outcomes.
Keyphrases
- liver failure
- ulcerative colitis
- end stage renal disease
- respiratory failure
- newly diagnosed
- ejection fraction
- chronic kidney disease
- drug induced
- staphylococcus aureus
- aortic dissection
- risk factors
- peritoneal dialysis
- prognostic factors
- cardiovascular disease
- cardiovascular events
- hepatitis b virus
- intensive care unit
- patient reported outcomes
- ultrasound guided
- mesenchymal stem cells
- insulin resistance