Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.

Marco RaffaeleKristina KovacovicovaJan FrohlichOriana Lo ReSebastiano GiallongoJude A ObenMartin FaldynaLenka LevaAntonino Giulio GiannoneDaniela CabibiManlio Vinciguerra

Published in: Cell communication and signaling : CCS (2021)

In summary, using an animal model that fully recapitulates NAFLD, we demonstrate that these compounds are ineffective against age-associated NAFLD-induced HCC. Video Abstract.

Keyphrases

chronic obstructive pulmonary disease
insulin resistance
high glucose
metabolic syndrome
weight loss
diabetic rats
type diabetes
weight gain
high fat diet induced
drug induced
adipose tissue
endothelial cells
physical activity
skeletal muscle
body mass index