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Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy.

Wenjuan WangErmin LiJianqiu ZouChen QuJuan AyalaYuan WenMd Sadikul IslamNeal L WeintraubDavid J R FultonQiangrong LiangJiliang ZhouJin-Bao LiuJie LiYi SunHuabo Su
Published in: Circulation research (2024)
These findings identify RBX2-CRL5 as a mitochondrial Ub ligase that regulates mitophagy and cardiac homeostasis in a Parkin-independent, PINK1-dependent manner.
Keyphrases
  • oxidative stress
  • nlrp inflammasome
  • left ventricular
  • heart failure
  • atrial fibrillation