Age of onset determines intrinsic functional brain architecture in Friedreich ataxia.

Gilles NaeijeVincent WensNicolas CoqueletMartin SjøgårdSerge GoldmanMassimo PandolfoXavier P De Tiège

Published in: Annals of clinical and translational neurology (2019)

Age of symptoms onset is a major determinant of FRDA patients' intrinsic functional brain architecture. Higher rsFC in FRDA patients with later age of symptoms onset supports compensatory mechanisms for FRDA-related neural network dysfunction and position neuromagnetic rsFC as potential marker of FRDA neural reserve.

Keyphrases

neural network
end stage renal disease
resting state
white matter
newly diagnosed
chronic kidney disease
ejection fraction
oxidative stress
early onset
functional connectivity
depressive symptoms
sleep quality
multiple sclerosis
risk assessment
climate change
brain injury