Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model.
Rohmad Yudi UtomoAtsushi SugieSatoshi OkadaKazuki MiuraHiroyuki NakamuraPublished in: Chemical communications (Cambridge, England) (2022)
Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.