Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain.

Paolo Zanotti-FregonaraBelen PascualMattia VeroneseMeixiang YuDavid BeersStanley H AppelJoseph C Masdeu

Published in: European journal of nuclear medicine and molecular imaging (2019)

11C-ER176 displays a higher binding potential and a smaller variability of VT values. Thanks to these characteristics, clinical studies performed with 11C-ER176 are expected to have higher statistical power and thus require fewer subjects.

Keyphrases

endoplasmic reticulum
estrogen receptor
breast cancer cells
optic nerve
binding protein
risk assessment
dna binding
climate change
transcription factor