Long-term use of selective digestive decontamination in an ICU highly endemic for bacterial resistance.
Catalina Sánchez-RamírezSilvia Hípola-EscaladaMiriam Cabrera-SantanaMaría Adela Hernández-VieraLiliana Caipe-BalcázarPedro SaavedraFernando Artiles-CampeloNayra Sangil-MonroyCarlos Federico Lübbe-VázquezSergio Ruiz-SantanaPublished in: Critical care (London, England) (2018)
Treatment with SDD during 4 years was effective in an ICU setting with a high level of resistance, with clinically relevant reductions of infections caused by MDRB, and with low rates of colistin- and tobramycin-resistant colonization with nonsignificant increasing rate of ICU colonization resistance by 1000 days, adjusted by the rate of resistances at ICU admission. In addition, VAP and secondary BSI rates were significantly lower after SDD. Notably, a decrease in antimicrobial consumption was also observed.