No Effect of Hypercholesterolemia on Elastase-Induced Experimental Abdominal Aortic Aneurysm Progression.

Toru IkezoeTakahiro ShojiJia GuoFanru ShenHong S Lu (吕红)Alan DaughertyMasao NunokawaHiroshi KubotaMasaaki MiyataBaohui XuRonald L Dalman

Published in: Biomolecules (2021)

This study demonstrated no recognizable impact of hypercholesterolemia on elastase-induced experimental AAA progression in both spontaneous and induced hypercholesterolemia mouse models. These results add further uncertainty to the controversy surrounding the efficacy of statin therapy in clinical AAA disease.

Keyphrases

high glucose
diabetic rats
abdominal aortic aneurysm
drug induced
mouse model
type diabetes
coronary artery disease
endothelial cells
low density lipoprotein