BCG Vaccine-associated Complications in a Large Cohort of Children With Combined Immunodeficiencies Affecting Cellular and Humoral Immunity.
Waleed Al HerzEntesar H HusainMehdi AdeliTariq Al FarsiSuleiman Al-HammadiAmna Ali Al KuwaitiMaryam Al-NesfNashat Al SukaitiSalem Al-TamemiHiba ShendiPublished in: The Pediatric infectious disease journal (2022)
Although contraindicated, many patients with CID continue to be vaccinated with BCG. Low CD8 + count is a risk factor for BCG-related complications and localized complications occurred earlier than disseminated ones. Considerations should be undertaken by health care authorities especially in countries with high incidence of CID to implement newborn screening, delay the time of BCG vaccine administration beyond 6 months of age and to use the relatively safer strains like the Danish and Tokyo ones.