Circulating MicroRNAs as Biomarkers of Osteoporosis and Fragility Fractures.

Simone CiuffiFrancesca MariniCaterina FossiSimone DonatiFrancesca GiustiAnnalisa BottaLaura MasiGiancarlo IsaiaClaudio MarcocciSilvia MigliaccioSalvatore MinisolaRanuccio NutiUmberto TarantinoTeresa IantomasiMaria Luisa Brandi

Published in: The Journal of clinical endocrinology and metabolism (2022)

Our study confirmed levels of c-miR-23a-3p and c-miR-21-5p as able to distinguish osteoporotic patients and subjects with normal BMD. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
bone mineral density
prognostic factors
cardiovascular disease
postmenopausal women
patient reported outcomes