Prognostic value of TERT promoter mutations in conjunctival melanomas in addition to clinicopathological features.
J A van IpenburgN C NausH J DubbinkR van GinderdeurenG S MissottenD ParidaensRobert M VerdijkPublished in: The British journal of ophthalmology (2020)
In line with the recommendations in the Eighth Edition of the American Joint Committee on Cancer Staging for CM, the pathology report should include information about pT status, tumour thickness, presence of epithelioid cells, ulceration and mitoses. Furthermore, information about the presence of a TERT promoter mutation and BRAF V600E mutation is of interest for therapeutic decision making. The presence of a TERT promoter mutation is correlated to metastatic disease.
Keyphrases
- dna methylation
- transcription factor
- gene expression
- decision making
- induced apoptosis
- squamous cell carcinoma
- lymph node
- health information
- papillary thyroid
- cell cycle arrest
- optical coherence tomography
- pet ct
- oxidative stress
- clinical practice
- cell proliferation
- signaling pathway
- metastatic colorectal cancer
- social media