Risk of hemorrhage and stricture significantly increases in elderly patients with proton pump inhibitor (PPI)-resistant reflux esophagitis.

Nana TakenouchiShintaro HoshinoYoshimasa HoshikawaTomohide TanabeMai KoedaEri MommaYumiko IshikawaNoriyuki KawamiMitsuru KaiseKatsuhiko Iwakiri

Published in: Esophagus : official journal of the Japan Esophageal Society (2019)

Among patients with proton pump inhibitor-resistant reflux esophagitis, the rates of severe reflux esophagitis and complications (hemorrhage and/or stricture) were significantly higher in elderly patients than in non-elderly patients. Regardless of age, 20 mg vonoprazan was effective for proton pump inhibitor-resistant reflux esophagitis.

Keyphrases

endoscopic submucosal dissection
helicobacter pylori
risk factors
electron transfer
small molecule
protein protein