Respiratory dysfunction in old mice could be related to inflammation and lung fibrosis induced by hyperphosphatemia.

Ana Asenjo-BuenoElena Alcalde-EstévezGemma OlmosPatricia Martínez-MiguelMaría Piedad Ruiz-TorresSusana López-Ongil

Published in: European journal of clinical investigation (2024)

These results suggest that age-related hyperphosphatemia induces inflammation, fibrosis, and impaired respiratory function in old mice; these effects appear to be mediated by ET-1 and NFkB activation.

Keyphrases

oxidative stress
high fat diet induced
respiratory tract
wild type
liver fibrosis
type diabetes
insulin resistance
metabolic syndrome