Hepatoprotective effect of N-acetylcysteine in trabectedin-induced liver toxicity in patients with advanced soft tissue sarcoma.

Salvatore GrisantiDeborah CosentiniValeria TovazziSusanna BianchiBarbara LazzariFrancesca ConsoliElisa RocaAlfredo BerrutiVittorio D Ferrari

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2018)

This explorative study suggests that NAC can have a hepatoprotective activity in patients receiving trabectedin allowing to maintain an adequate dose intensity and continuative administration in patients with impaired liver and renal function or developing treatment-induced hepatotoxicity. A prospective randomized trial is warranted.

Keyphrases

high glucose
drug induced
diabetic rats
oxidative stress
transcription factor