Fast and accurate diffusion NMR acquisition in continuous flow.

Isabel A ThomlinsonMatthew G DavidsonCatherine L Lyall John P Lowe Ulrich Hintermair

Published in: Chemical communications (Cambridge, England) (2022)

FlowNMR spectroscopy has become a popular and powerful technique for online reaction monitoring. DOSY NMR is an established technique for obtaining information about diffusion rates and molecular size on static samples. This work extends the FlowNMR toolbox to include FlowDOSY based on convection compensation and use of a low-pulsation pump or flow effect correction, allowing accurate and precise diffusion coefficients to be obtained at flow rates up to 4.0 mL min -1 in less than 5 minutes.

Keyphrases

high resolution
solid state
magnetic resonance
single molecule
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