Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling.
Shumei ZhaoJiaqi LuoJun HuHesheng WangNingwei ZhaoMeng CaoCong ZhangRongkui HuLan-Ying LiuPublished in: Mediators of inflammation (2022)
Ezrin is an actin binding protein connecting the cell membrane and the cytoskeleton, which is crucial to maintaining cell morphology, intercellular adhesion, and cytoskeleton remodeling. Asthma involves dysfunction of inflammatory cells, cytokines, and airway structural cells. Recent studies have shown that ezrin, whose function is affected by extensive phosphorylation and protein interactions, is closely associated with asthma, may be a therapeutic target for asthma treatment. In this review, we summarize studies on ezrin and discuss its role in asthma-related airway inflammation and remodeling.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- allergic rhinitis
- induced apoptosis
- binding protein
- oxidative stress
- cell cycle arrest
- air pollution
- cystic fibrosis
- stem cells
- escherichia coli
- mesenchymal stem cells
- staphylococcus aureus
- case control
- biofilm formation
- amino acid
- smoking cessation
- protein protein