Mitochondria-targeted biotin-conjugated BODIPYs for cancer imaging and therapy.
Dhiraj DuttaRajshree R NairKashmiri NeogS Asha NairPranjal GogoiPublished in: RSC medicinal chemistry (2023)
Two BODIPY-biotin conjugates KDP1 and KDP2 are designed and synthesized for targeted PDT applications. Both have good absorption with a high molar absorption coefficient and decent singlet oxygen generation quantum yields. The photosensitizers KDP1 and KDP2 were found to be localized in the mitochondria with excellent photocytotoxicity of up to 18.7 nM in MDA-MB-231 breast cancer cells. The cell death predominantly proceeded through the apoptosis pathway via ROS production.
Keyphrases
- cell death
- photodynamic therapy
- cell cycle arrest
- breast cancer cells
- cancer therapy
- fluorescence imaging
- papillary thyroid
- high resolution
- reactive oxygen species
- molecular dynamics
- drug delivery
- energy transfer
- squamous cell carcinoma
- fluorescent probe
- stem cells
- endoplasmic reticulum stress
- computed tomography
- mass spectrometry
- african american
- bone marrow
- pi k akt
- mesenchymal stem cells
- dna damage
- smoking cessation
- quantum dots
- cell therapy