Comtrifosides A and B, two new triterpenoid saponins from the leaves of Combretum trifoliatum .
Cong Thai Son NguyenThanh Hoa VoNguyen Kim Tuyen PhamBui Linh Chi HuynhTrong Nghia NgoVan Son DangThi Kim Chi HuynhTrong Dat BuiDiep Xuan Ky NguyenNhat Minh PhanDinh Tri MaiKim Phi Phung NguyenNguyen Kim Tuyen PhamPublished in: Natural product research (2024)
The phytochemical composition of the Combretum trifoliatum leaves was studied for the first time. Two new triterpenoid saponins, named comtrifoside A ( 1 ) and comtrifoside B ( 2 ), together with two other saponins ( 3-4 ) were purified by variously chromatographic techniques. For the first time, compound 3 was informed from the Combretum genus, as well as all of the isolated compounds ( 1-4 ) were reported from C. trifoliatum . The chemical structures of them were clearly characterised using extensive UV-VIS, IR, HRMS-ESI, and NMR experimental data. The in vitro anti-inflammatory activities of 1 & 2 were examined against NO overproduction in LPS activation of RAW264.7.