Umpolung of o-Hydroxyaryl Azomethine Ylides: Entry to Functionalized γ-Aminobutyric Acid under Phosphine Catalysis.

Qingqing ChenYishu BaoXiuqin YangZonghao DaiFulai Yang Qingfa Zhou

Published in: Organic letters (2018)

A phosphine-catalyzed reaction between o-hydroxyaryl azomethine ylides and MBH carbonates provides access to highly functionalized γ-aminobutyric acid derivatives in moderate to good yields. Mechanistically, the reaction involves a phosphine-catalyzed tandem SN2'/2-aza-Cope rearrangement/intramolecular addition process.

Keyphrases

room temperature
quantum dots
molecularly imprinted
high intensity
electron transfer
energy transfer
ionic liquid
liquid chromatography