Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma.
Hesam MovassaghMary M PrunickiAbhinav KaushikXiaoying ZhouDiane DunhamEric M SmithZiyuan HeGerman R Aleman MuenchMinyi ShiAnnika K WeimerShu CaoSandra AndorfAmir FeiziMichael P SnyderPejman SorooshElizabeth D MellinsKari Christine NadeauPublished in: Allergy (2023)
The specific alterations of monocytes after ambient pollution exposure suggest a possible prognostic immune signature for pediatric asthma, and pollution-induced trained immunity may provide a potential therapeutic target for asthmatic children living in areas with increased air pollution.
Keyphrases
- air pollution
- lung function
- particulate matter
- heavy metals
- human health
- chronic obstructive pulmonary disease
- risk assessment
- resistance training
- health risk assessment
- dendritic cells
- young adults
- cystic fibrosis
- diabetic rats
- allergic rhinitis
- body composition
- oxidative stress
- climate change
- immune response
- high intensity