Plasma transfusion-transmission of Zika virus in mice and macaques.
Koen K A Van RompayLark L CoffeyJoAnn L YeeAnil SingapuriJackson StuartMarion C LanteriFelicia Santa MariaKai LuInderdeep SinghSonia Bakkour CocoMars StonePhillip C WilliamsonMarcus O MuenchMichael P BuschGraham SimmonsPublished in: Transfusion (2023)
Significant risks of ZIKV TT are likely confined to a relatively short viremic window before seroconversion, and that sensitive nucleic acid amplification testing likely identifies the majority of infectious plasma. PRT was demonstrated to be effective at preventing ZIKV TT. Considering that there is no approved ZIKV vaccine, these data are relevant to mitigate the risk of TT during the future ZIKV outbreaks.