Progression of Clinical and Eye Movement Markers in Preataxic Carriers of Machado-Joseph Disease.
Camila Maria de OliveiraVanessa Bielefeldt LeottiAmanda Henz CappelliAnastacia Guimarães RochaGabriela EccoGabriela BolzanNathalia KerstingMaria-Luiza Saraiva-PereiraLaura Bannach JardimPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
NESSCA, INAS, vestibulo-ocular reflex, and vertical pursuit gains significantly worsened in the preataxic phase. The "TimeToAfterOnset" timeline unveiled that slopes of most variables are small in preataxics but increase and reach the ataxic slopes from 4 years before the onset of ataxia. For future trials in preataxic carriers, we recommend recruiting PANs and using the conversion rate as the primary outcome. © 2022 International Parkinson and Movement Disorder Society.