Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion.

Mustafa YalcinkayaPanagiotis FotakisWenli LiuKaori Endo-UmedaHuijuan DouSandra AbramowiczTong XiaoPeter LibbyNan WangAlan R TallMarit Westerterp

Published in: Cardiovascular research (2022)

These studies establish a new link between inflammasome mediated IL-1β production in macrophages and NETosis in atherosclerotic plaques. Macrophage-derived IL-1β appears to increase NETosis both by increasing neutrophil recruitment to plaques and by promoting neutrophil NLRP3 inflammasome activation.

Keyphrases

nlrp inflammasome
adipose tissue