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Bridging therapies for patients with hepatocellular carcinoma awaiting liver transplantation: A systematic review and meta-analysis on intention-to-treat outcomes.

Marcello Di MartinoDaniele FerraroDonatella PisanielloGiuseppe ArengaFederica FalaschiAlfonso TerroneMarilisa ManiscalcoAlfonso Galeota LanzaCiro EspositoGiovanni Vennarecci
Published in: Journal of hepato-biliary-pancreatic sciences (2022)
Patients submitted to bridging procedures, despite having a longer interval on the waiting list, presented better post-LT survival outcomes. Bridging therapies for selected patients at low risk of post-procedural complications and long expected intervals on the waiting list should be encouraged. However, further clinical trials should confirm the survival benefit of bridging therapies in patients with HCC listed for LT.
Keyphrases
  • end stage renal disease
  • clinical trial
  • ejection fraction
  • chronic kidney disease
  • prognostic factors
  • patient reported outcomes
  • metabolic syndrome
  • insulin resistance
  • patient reported
  • weight loss
  • open label